Findings consistent with the hypothesis that increased central opioidergic tone contributes to the pruritus of cholestasis provide a rationale for treating this form of pruritus with opiate antagonists. However, initiation of therapy with an opiate antagonist in a cholestatic patient may precipitate a transient opioid withdrawal-like reaction.

As opiate agonists (e.g. morphine) mediate analgesia, increased opioidergic tone in cholestasis should be associated with a decreased response to pain. To test this hypothesis, the response of rats with acute cholestasis to a nociceptive stimulus was measured by the use of the tail-flick test, an extensively validated assay for measuring opiate-induced antinociception.

The source of increased levels of endogenous opioids in cholestasis is not clear, but may be the liver itself.18 Pruritus: ↑ opioidergic tone • Several lines of evidence support a role for an ↑ opioidergic tone in the pathogenesis of pruritus in PBC. • First, as opposed to healthy volunteers, pts with PBC develop withdrawal- like symptoms after taking an opioid antagonist. A loss of inhibitory opioidergic tone likely occurs at the DRt since monoarthritic rats show decreased expression levels of of µ - and δ -opioid receptors at the DRt ( Neto et al., 2008; Se hela listan på frontiersin.org 2018-06-28 · It is possible that very subtle µ-opioid modulation by the combination may be sufficient to ameliorate dysregulated or impaired endogenous opioidergic tone in depressed patients. Substances of abuse dysregulate key brain systems involved in motivation, reward, decision-making and memory. As drug use evolves into a compulsive addiction, there are adaptations in these systems, mediated by a number of different neurotransmitters.

In the present study, we attempted to examine the opioidergic inhibitory tone imposed on GnRH release mechanism in elderly men by monitoring the plasma gonadotropin response to the opiate receptor antagonist naloxone hydrochloride. Following the naloxone administration in bile duct resected animals, striking opioid withdrawal signs are observed due to increased opioidergic tone. Pretreatment of animals with L-nitro arginine, a nitric oxide synthase inhibitor, reduces the naloxone-precipitated withdrawal signs as … 2002-08-01 Opioidergic. Opioidergic descending pain control in the hypothalamus, PAG and RVM underlied placebo analgesia using MRI [173]. From: Peptides, 2010.

Examples include opioid analgesics such as morphine and opioid antagonists such as naloxone .

In particular, the hypothesis that increased central opioidergic tone is involved is supported by three observations: opiate agonists induce opioid receptor-mediated scratching activity of central origin, central opioidergic tone is increased in cholestasis and opiate antagonists reduce scratching activity in cholestatic patients.

However, chronic use is often associated with tolerance as well as debilitating side effects, including nausea and depen In particular, the hypothesis that increased central opioidergic tone is involved is supported by three observations: opiate agonists induce opioid receptor-mediated scratching activity of central origin, central opioidergic tone is increased in cholestasis and opiate antagonists reduce scratching activity in cholestatic patients. However, luteinizing hormone (LH) pulse frequency and pulse amplitude were not affected by naloxone treatment. Further, chronic naloxone treatment of zebu heifers did not induce puberty;In a follow-up study, the effects of dietary restriction and endogenous opioidergic tone on the regulation of progesterone, cortisol and LH were investigated. Analogous to the pruritus that results from the pharmacological increase in opioidergic tone by central morphine ( 4,5 ), it is hypothesized that increased opioidergic tone in cholestasis may mediate the pruritus, at least in part, by a central mechanism ( 6 ).

However, luteinizing hormone (LH) pulse frequency and pulse amplitude were not affected by naloxone treatment. Further, chronic naloxone treatment of zebu heifers did not induce puberty;In a follow-up study, the effects of dietary restriction and endogenous opioidergic tone on the regulation of progesterone, cortisol and LH were investigated.

Lippincott Journals Subscribers, use your username or email along with your password to log in., use your username or email along with your password to log in. This approach was based on evidence that patients with AD show increased CSF levels of opioid peptides and a reduction in opioid binding receptors in the dentate gyrus. 20,29,33 In this study, the opioid receptor antagonist, naloxone, induced an increase in sensitivity to thermal stimulation suggesting that increased opioidergic tone in the transgenic mice is responsible for the altered The present studies examined the influence of alterations in central opioidergic tone to initiate the LH surge, and the roles of oestradiol and progesterone to effect changes in opioidergic tone, by antagonizing this activity using either naloxone or nalmefene (N-cyclopropylmethyl-6-desoxy-6-methylene-noroxy-morphone), a long-acting mu- and kappa-opiate antagonist. 2016-10-01 Download PDF: Sorry, we are unable to provide the full text but you may find it at the following location(s): http://europepmc.org/articles/ (external link) Summary: The role of opioidergic system in controlling gonadotropin secretion in elderly men still remains uncertain. In the present study, we attempted to examine the opioidergic inhibitory tone imposed on GnRH release mechanism in elderly men by monitoring the plasma gonadotropin response to the opiate receptor antagonist naloxone hydrochloride.

2012-08-01 · Also, the raised incidence of silent myocardial ischemia in athletes may be explained by raised opioidergic tone, thereby blunting the alerting pain symptoms of ischemia. Pain threshold elevations induced by regular exercise are reversed by the opioid receptor antagonist naloxone [53] and the antinociceptive effects of exogenous opiates are attenuated by exercise, a phenomenon referred to as opioidergic systems interacting with the nucleus accumbens shell affect ethanol intake and addiction-related behaviors per se. A high innate µ-opioidergic tone in the nucleus accumbens shell of alcohol-preferring Alko Alcohol (AA) rats has been proposed to account for The effects of JDTic on relapse-like ethanol intake in Long-Evans rats was examined because of the positive results from the previous study, earlier reports suggesting an increased tone of the accumbal κ-opioidergic system as ethanol addiction evolves and the lack of knowledge on what role the nucleus accumbens shell κ-opioid receptors have in relapse to ethanol intake. Reduced thermal sensitivity and increased opioidergic tone in the TASTPM mouse model of Alzheimer's disease. Aman Y, Pitcher T, Simeoli R, Ballard C, Malcangio M Pain.

Related terms: Neurotransmitter; Dopamine; Naloxone; Gonadotropin-Releasing Hormone; Beta-Endorphin; Serotonergic; Dopaminergic; Opioid Receptor; Opioid peptides However, the underlying mechanism for this observation remains elusive owing to the increased opioidergic tone detected in the transgenic model of AD, which would suggest a reduced sensitivity to exogenous opioid agonist, morphine (Smith and Yancey, 2003). Therefore, these results implicate a possible regulation of the opioidergic system in AD. Summary: The role of opioidergic system in controlling gonadotropin secretion in elderly men still remains uncertain.
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increase in opioidergic tone (and thus no danger of a withdrawal syndrome if an opioid antagonist is given). Instead, the ratio between m-opioid (pruritus-inducible) and k-opioid (pruritus-suppressive) re-ceptors alters in favor of the former.69,70 This predisposes to the onset or exacerbation of pruritus. It 2.

20,29,33 In this study, the opioid receptor antagonist, naloxone, induced an increase in sensitivity to thermal stimulation suggesting that increased opioidergic tone in the transgenic mice is responsible for the altered thermal thresholds. The present studies examined the influence of alterations in central opioidergic tone to initiate the LH surge, and the roles of oestradiol and progesterone to effect changes in opioidergic tone, by antagonizing this activity using either naloxone or nalmefene (N-cyclopropylmethyl-6-desoxy-6-methylene-noroxy-morphone), a long-acting mu- and kappa-opiate antagonist.

Opioidergic. Opioidergic descending pain control in the hypothalamus, PAG and RVM underlied placebo analgesia using MRI [173]. From: Peptides, 2010. Related terms: Neurotransmitter; Dopamine; Naloxone; Gonadotropin-Releasing Hormone; Beta-Endorphin; Serotonergic; Dopaminergic; Opioid Receptor; Opioid peptides

Six normal young men and 10 elderly men with opioidergic tone in the CNS and that opiate antagonists can ameliorate,atleastpartially,thisformofpruritus.Thefirstof these requirements is discussed in the next paragraph and the second in the section on treatment with neurotransmit-ter receptor antagonists. Substances of abuse dysregulate key brain systems involved in motivation, reward, decision-making and memory. As drug use evolves into a compulsive addiction, there are adaptations in these systems, mediated by a number of different neurotransmitters. The mesolimbic dopaminergic pathway plays a central role in the pleasurable and positive reinforcing effects of drugs.

There are wakefulness/sleep and opioidergic modulation of noxious stimulation. These. that dyskinesias are associated with a heightened opioid cotransmitter tone, A role for enhanced peptidergic transmission, either opioidergic or not, has that dyskinesias are associated with a heightened opioid cotransmitter tone, A role for enhanced peptidergic transmission, either opioidergic or not, has Opioidergic System. opioidergic system. Opioidergic. opioidergic.